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Conclusion Our data indicate that the changing drug policy during 2008–2011, which provided the ACT, in the form of CoArtem, on subsidy in private retail shops and freely in public hospitals, had an effect on drugs used during the same period

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Keywords: Metformin, Vitamin B12 deficiency, Metformin-induced cobalamin deficiency, Diabetes, Type 2 diabetes, Prediabetes, Screening criteria, Neuropathy, Anemia Core Tip: Over the last decades, vitamin B12 deficiency has been increasingly recognized as a possible consequence of long-term metformin therapy, potentially resulting in clinical manifestations such as hematologic abnormalities and peripheral neuropathy